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September 13, 2023Science AdvancesOpen Access

IFN-λ acts on tuft cells to limit infection, and MAVS in nonsusceptible enterocytes restricts MNoV, indicating noninfected cells are the IFN-λ source.

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Why the study?

Norovirus causes epidemic gastroenteritis with no approved vaccines or antivirals, and the source and mechanisms of IFN-λ regulation against persistent infection remained to be defined.

Population

Murine norovirus in vivo model

Design

Preclinical animal and cellular study

Authors

HIHarshad IngleHMHeyde MakimaaSASomya Aggarwal

Discussion

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Overview

IFN-λ effects on tuft cells remain hypothesis-generating for norovirus persistence; leaves open human translation and therapeutic targeting.

Structured PICO

P
Population
Murine norovirus (MNoV) in vivo model
I
Intervention
Interferon-λ (IFN-λ) and MDA5-MAVS signaling
O
Outcome
Control of persistent MNoV infectionsurrogate

Host sensing of MNoV occurs in nonsusceptible enterocytes which produce IFN-λ that acts on infected tuft cells to limit persistent infection.

Cite This Study

Ingle et al. (2023) studied this question.

synapsesocial.com/papers/6a6f8500f44fa9f079dcf904https://doi.org/10.1126/sciadv.adi2562
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