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November 28, 2014Science

Treatment of established infection with IFN-λ cured mice in a manner requiring nonhematopoietic cell expression of the IFN-λ receptor, Ifnlr1, and independent of adaptive immunity.

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Why the study?

Does interferon-λ cure persistent murine norovirus infection in mice?

Population

Mice with persistent murine norovirus (MNoV) infection

Design

Preclinical

Authors

TNTimothy J. NiceMBMegan T. BaldridgeBMBroc T. McCune

Discussion

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Overview

IFN-λ merits investigation for human enteric viruses; leaves open translation from this murine model.

Structured PICO

Does interferon-λ cure persistent murine norovirus infection in mice?

P
Population
Mice with persistent murine norovirus (MNoV) infection
I
Intervention
Interferon-λ (IFN-λ)
O
Outcome
Cure of persistent enteric infectionsurrogate

IFN-λ cures persistent murine norovirus infection in the gastrointestinal tract independent of adaptive immunity, suggesting therapeutic potential for enteric viral infections.

Cite This Study

Nice et al. (2014) studied this question.

synapsesocial.com/papers/6a8257c0546f28f189795e2bhttps://doi.org/10.1126/science.1258100
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