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June 29, 2017Frontiers in ImmunologyOpen Access

Interferon-lambda acts as a critical innate immune regulator that controls multiple intestinal viruses, including rotavirus, reovirus, and norovirus, and interacts with the commensal microbiome.

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Design

Review

Key result

Interferon-lambda acts as a critical innate immune regulator that controls multiple intestinal viruses, including rotavirus, reovirus, and norovirus, and interacts with the commensal microbiome.

Authors

SLSanghyun LeeMBMegan T. Baldridge

Discussion

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Member takes

Overview

No clinical adoption for enteric viruses yet; leaves open therapeutic targeting in prospective trials.

Structured PICO

E
Exposure
Interferon-lambda (IFN-λ)

This review highlights the critical role of interferon-lambda in the innate immune regulation of intestinal viral infections, suggesting its therapeutic potential for enteric viruses.

Limitations

  • Most previous studies were performed in vitro or in animal models outside the complex environment of the human gut.
  • Lack of data on IFN-lambda sensitivity for several other enteric viruses like astroviruses and adenoviruses.
  • The in vivo effect of IFN-lambda regulation on enteric viruses in humans remains largely unknown.

Cite This Study

Lee et al. (2017) conducted a review in Intestinal viral infections. Interferon-lambda (IFN-λ) was evaluated. Interferon-lambda acts as a critical innate immune regulator that controls multiple intestinal viruses, including rotavirus, reovirus, and norovirus, and interacts with the commensal microbiome.

synapsesocial.com/papers/6a95b112ef8b500123f9f067https://doi.org/10.3389/fimmu.2017.00749
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Expression of <i>Ifnlr1</i> on Intestinal Epithelial Cells Is Critical to the Antiviral Effects of Interferon Lambda against Norovirus and Reovirus2017 · 167 citations
  2. 2Interferon lambda in anti-viral defense and cancer: dual roles, mechanism and therapeutic potential2026 · 1 citations
  3. 3Interferon lambda in respiratory viral infection: immunomodulatory functions and antiviral effects in epithelium2024 · 11 citations
  4. 4IFN-λ determines the intestinal epithelial antiviral host defense2011 · 423 citations
  5. 5Interferon-λ cures persistent murine norovirus infection in the absence of adaptive immunity2014 · 353 citations