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April 25, 2011Proceedings of the National Academy of SciencesOpen Access

IFN-λ determines the intestinal epithelial antiviral host defense

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Population

Suckling and adult mice

Comparison

Systemic treatment with IFN-λ or type I IFN… vs Wild-type mice or mice lacking functional…

Design

Preclinical

Authors

JPJohanna PottTMTanel MahlakõivMMMarkus Mordstein

Discussion

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Overview

No immediate clinical implications; leaves open whether IFN-λ agonists merit human trials for intestinal viruses.

Structured PICO

P
Population
Suckling and adult mice (wild-type, lacking functional receptors for IFN-λ, and lacking functional receptors for type I IFN)
I
Intervention
Systemic treatment with IFN-λ or type I IFN; oral rotavirus infection
C
Comparator
Wild-type mice or mice lacking functional receptors for type I IFN
O
Outcome
Control of oral rotavirus infection and viral replicationsurrogate

IFN-λ plays a critical, nonredundant role in the epithelial antiviral host defense against intestinal rotavirus infection in vivo.

Cite This Study

Pott et al. (2011) studied this question.

synapsesocial.com/papers/6a7150f1e5469ee92be1e1adhttps://doi.org/10.1073/pnas.1100552108
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