Key result
The DBA/2 mouse strain demonstrated a more immature cardiac phenotype, including a higher percentage of cardiac progenitor cells (4.2% vs 2.5%) and a greater hypertrophic response to isoproterenol.
Why the study?
Does mouse strain (C57BL/6 vs DBA/2) determine cardiac growth potential and response to hypertrophic stimulation?
Population
C57BL/6 and DBA/2 mouse strains
Comparison
2-week isoproterenol stimulation vs Unstimulated controls and between-strain…
Design
Preclinical
Follow-up
2 weeks
Authors
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Strain choice may alter cardiac phenotype and hypertrophy in mice; leaves open optimal models for heart disease research.
Does mouse strain (C57BL/6 vs DBA/2) determine cardiac growth potential and response to hypertrophic stimulation?
Absolute Event Rate: 4.2% vs 2.5%
p-value: p=<0.05
The DBA/2 mouse strain exhibits a more immature cardiac phenotype and a greater hypertrophic response to isoproterenol compared to C57BL/6, highlighting the critical role of genetic background in selecting mouse models for heart disease research.
Kiper et al. (2013) studied Cardiac hypertrophy and aging. DBA/2 genetic background vs. C57BL/6 genetic background was evaluated on Percentage of c-kit+ cardiac progenitor cells at 8 weeks (p=<0.05). The DBA/2 mouse strain demonstrated a more immature cardiac phenotype, including a higher percentage of cardiac progenitor cells (4.2% vs 2.5%) and a greater hypertrophic response to isoproterenol.
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