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May 1, 2003Experimental Physiology

Cardiomyocyte Death and the Ageing and Failing Heart

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Population

Rat heart in vivo model

Design

Review

Authors

DGDavid F. GoldspinkLiverpool John Moores UniversityJBJatin G. BurnistonLiverpool John Moores UniversityLTLip‐Bun TanLeeds General Infirmary

Discussion

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Overview

Necrosis predominates in catecholamine cardiotoxicity; hypothesis-generating for sympathetic mechanisms in human heart failure progression.

Structured PICO

P
Population
Rat heart in vivo model
I
Intervention
Single injection of natural or synthetic catecholamine
O
Outcome
Cardiomyocyte apoptosis (identified by anti-caspase 3 antibody) and necrosis (identified by anti-myosin antibody)surrogate

Catecholamine-induced cardiomyocyte death involves both apoptosis and necrosis, suggesting a mechanism for heart failure progression driven by sympathetic over-activation.

Cite This Study

Goldspink et al. (2003) studied this question.

synapsesocial.com/papers/6a955406d002db7cabf59596https://doi.org/10.1113/eph8802549

Topics

Heart failureHFrEF treatment
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Also Consider

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  1. 1Firing Properties of Single Muscle Vasoconstrictor Neurons in the Sympathoexcitation Associated With Congestive Heart Failure1999 · 97 citations
  2. 2Prolonged exercise alters beta-adrenergic responsiveness in healthy sedentary humans1996 · 54 citations
  3. 3Mitochondria and Apoptosis1998 · 9,046 citations
  4. 4Characterization of Adrenoceptor Involvement in Skeletal and Cardiac Myotoxicity Induced by Sympathomimetic Agents: Toward a New Bioassay for β-blockers2003 · 43 citations
  5. 5Age and Gender Effects on Cardiomyocyte Apoptosis in the Normal Human Heart2001 · 111 citations