Key result
Patients with spinal muscular atrophy exhibited significantly higher normalized sEMG amplitudes at onset of upper body endurance tests compared to controls, revealing motor unit reserve capacity.
Why the study?
To investigate whether patients with spinal muscular atrophy have motor unit reserve capacity available during fatiguing endurance testing.
Is motor unit reserve capacity available during fatiguing endurance testing in patients with spinal muscular atrophy compared to healthy controls?
Population
70 patients with SMA types 2-4 and 19 healthy controls
Comparison
Patients with SMA types 2-4 vs healthy controls during endurance shuttle tests
Authors
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Supports motor unit reserve in SMA; hypothesis-generating for fatigability interventions.
Observational (n=89)
Is motor unit reserve capacity available during fatiguing endurance testing in patients with spinal muscular atrophy compared to healthy controls?
Patients with SMA demonstrate motor unit reserve capacity during submaximal endurance tasks, suggesting a potential therapeutic target to reduce fatigability.
Habets et al. (2021) conducted an observational in Spinal muscular atrophy (n=89). Spinal muscular atrophy (SMA) types 2-4 vs. Healthy controls was evaluated on Development of fatigability and motor unit recruitment using time courses of median frequencies and amplitudes of sEMG signals. Patients with spinal muscular atrophy exhibited significantly higher normalized sEMG amplitudes at onset of upper body endurance tests compared to controls, revealing motor unit reserve capacity.
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