Key result
A newly developed totally implantable mechanical circulatory assist device demonstrated effective function during 1-4 years of in vitro testing and 1.5 to 96 hours of in vivo bovine experiments.
A newly developed totally implantable mechanical circulatory assist device demonstrated effective function and durability in in vitro and short-term bovine models.
Answers are grounded in this paper and cite their sources.
Should not yet guide clinical MCS decisions; hypothesis-generating for durable implantable devices pending human trials.
A mechanical circulatory assist device for long term use outside the hospital setting has been developed. The device can be used for left, right or bi-ventricular support, and several of the developed technologies are applicable for total artificial hearts and non-pulsatile flow systems. The totally implantable device is principally designed for left ventricular support with implantation in the left hemithorax. The system utilizes transcutaneous energy and information transfer sub-systems, and has no percutaneous connections. In vitro durability testing has been conducted for periods from 1-4 years. Bovine experiments have been conducted with sustained circulation for periods form 1.5 to 96 hours. The in vitro and in vivo evaluation to date has demonstrated that the system can function effectively as a totally implantable ventricular assist device. The transcutaneous energy and information transfer sub-systems provided the ability to power, monitor and control the device, without the need for percutaneous connections. Design optimization and chronic in vivo evaluation is planned.
No takes yet. Share an insight, caveat, or question.
Mussivand et al. (1997) studied this question. Multi-Purpose Mechanical Circulatory Device was evaluated on Device function and durability. A newly developed totally implantable mechanical circulatory assist device demonstrated effective function during 1-4 years of in vitro testing and 1.5 to 96 hours of in vivo bovine experiments.
Synapse has enriched 10 related papers. Consider them for comparative context: