Key result
Cumulative exposure to guideline-directed medical therapy goals was associated with a lower incidence of all-cause mortality or nonfatal myocardial infarction.
Why the study?
The study evaluated the relationship between cardiovascular GDMT goal achievement and clinical outcomes in patients with CKD G5D versus CKD G4-5.
Does achievement of cardiovascular guideline-directed medical therapy goals reduce all-cause mortality or nonfatal myocardial infarction in patients with advanced CKD and chronic coronary disease?
RCT (n=777)
randomized
Yes
Does achievement of cardiovascular guideline-directed medical therapy goals reduce all-cause mortality or nonfatal myocardial infarction in patients with advanced CKD and chronic coronary disease?
Attainment of cardiovascular GDMT goals is associated with improved clinical outcomes in patients with advanced CKD and chronic coronary disease, though dialysis patients are less likely to receive statins and aspirin.
Answers are grounded in this paper and cite their sources.
Supports GDMT attainment in advanced CKD with CAD; extends evidence to this population but remains hypothesis-generating.
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Mathew et al. (2022) conducted an RCT in Advanced chronic kidney disease and chronic coronary disease (n=777). Guideline-directed medical therapy (GDMT) goal achievement was evaluated on all-cause mortality or nonfatal myocardial infarction (HR 0.88, 95% CI 0.87-0.90). Cumulative exposure to guideline-directed medical therapy goals was associated with a lower incidence of all-cause mortality or nonfatal myocardial infarction.
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