Key result
In male patients with arterial hypertension, higher PCSK9 levels (>580 ng/mL) were associated with more severe coronary artery atherosclerosis and increased cardiovascular risk (P=0.002).
Why the study?
The relationship between proprotein convertase subtilisin kexin type 9 levels and atherosclerosis of coronary and brachiocephalic arteries in patients with arterial hypertension required investigation.
Do higher PCSK9 levels correlate with increased severity of coronary and brachiocephalic atherosclerosis in male patients with arterial hypertension?
Cross-Sectional (n=161)
No
Do higher PCSK9 levels correlate with increased severity of coronary and brachiocephalic atherosclerosis in male patients with arterial hypertension?
Answers are grounded in this paper and cite their sources.
Higher PCSK9 levels are associated with more severe coronary and brachiocephalic atherosclerosis in male patients with arterial hypertension, independent of traditional risk factors.
BACKGROUND: Aim of our investigation is to study the relationship between the level of proprotein convertase subtilisin kexin type 9 (PCSK9) and atherosclerotic process of coronary and brachiocephalic arteries in patients with arterial hypertension (AH).METHODS: Our investigation was performed in regional railway hospital. In our investigation we included 161 male train drivers who had AH with achieved target grades 1-2. All patients were performed laboratory tests including cholesterol, LDL-C, triglycerides, glucose, hemostasiograms, PCSK9. Patients were divided into groups up to the PCSK9 level: in group 1 (N.=41) we included patients with PCSK9 level 108-250 ng/mL; group 2 (N.=37) 251-400 ng/mL; group 3 (N.=45) 420-560 ng/mL and group 4 (N.=38) 580-860 ng/mL. All patients were performed coronary angiography, ultrasound Doppler of brachiocephalic arteries, electrocardiography, transthoracic echocardiography.RESULTS: The groups of the patients were identical in age, Body Mass Index, triglycerides, LDL-C, glucose, cholesterol levels. Also, there was no significant difference in the dependence of PCSK9 level on smoking status (χ2=3.1; P=0.3) and the presence of family history of AH (χ2=0.9; P=0.8). It was found that in the 1st group, patients with normal Body Mass Index had normal carotid intima-media thickness ≤1 mm in most of the cases (34.1%). The severity of brachiocephalic and coronary arteries atherosclerosis was more advanced in the 4th group. The atherosclerotic plaques determine the cardiovascular risk in patients with AH.CONCLUSIONS: The level of PCSK9 in male patients is an additional cardiovascular risk factor independent from the traditional risk factors. The PCSK9 level is correlated with atherosclerotic severity process of brachiocephalic arteries (P=0.08; r=0.2). The concentration of PCSK9 in the blood serum more than 580 ng/mL in patients with AH determines more severe coronary arteries atherosclerosis. If more the level of PCSK9 than more cardiovascular risk (P=0.002).
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VUKOLOVA et al. (2022) conducted a cross-sectional in Arterial hypertension (n=161). PCSK9 level vs. Lower PCSK9 levels was evaluated on Atherosclerotic severity of brachiocephalic and coronary arteries and cardiovascular risk (r=0.2, p=0.002). In male patients with arterial hypertension, higher PCSK9 levels (>580 ng/mL) were associated with more severe coronary artery atherosclerosis and increased cardiovascular risk (P=0.002).
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