Key result
An overdose of eperisone and triazolam in a patient receiving nifedipine caused severe QTc prolongation (820 ms) and torsades de pointes requiring a temporary cardiac pacemaker.
Why the study?
Does an overdose of eperisone and triazolam cause severe QT prolongation and torsades de pointes?
Case Report (n=1)
Does an overdose of eperisone and triazolam cause severe QT prolongation and torsades de pointes?
An overdose of eperisone and triazolam can cause severe QTc prolongation and life-threatening torsades de pointes, highlighting the need for electrocardiographic monitoring in such patients.
Answers are grounded in this paper and cite their sources.
May support ECG monitoring in eperisone-triazolam overdose; leaves open causality and generalizability.
INTRODUCTION: Eperisone hydrochloride is a centrally acting muscle relaxant, and triazolam is a short-acting benzodiazepine. Although commonly prescribed, cardiotoxicity induced by a single overdose of either drug is comparatively rare. A patient receiving nifedipine developed torsades de pointes (TdP) because of prolongation of the corrected QT (QTc) interval after an overdose of eperisone hydrochloride and triazolam. CASE REPORT: A 60-year-old man receiving nifedipine was admitted in a comatose condition 3 h after ingesting 5,000 mg of eperisone and 2.5 mg of triazolam. Electrocardiogram showed sinus rhythm with prolongation of the QTc interval (820 ms). The serum electrolyte levels were as follows: potassium, 3.8 mEq/L; magnesium, 2.4 mg/dL. The serum drug concentrations were high: eperisone, 15,360 ng/mL; triazolam, 110.8 ng/mL. A temporary cardiac pacemaker was implanted immediately after the development of TdP, 11 h after the ingestion. The serum triazolam concentration normalized on day 2. The QTc interval and eperisone concentration normalized on day 6. CONCLUSION: Eperisone and triazolam overdose can cause life-threatening cardiotoxicity. Electrocardiographic monitoring and serial determination of QTc interval are likely the best way to observe these patients and evaluate the risk of cardiotoxicity.
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Yamagiwa et al. (2010) conducted a case report in Torsades de pointes and severe QT prolongation (n=1). Eperisone and triazolam overdose was evaluated on Development of torsades de pointes and QTc prolongation. An overdose of eperisone and triazolam in a patient receiving nifedipine caused severe QTc prolongation (820 ms) and torsades de pointes requiring a temporary cardiac pacemaker.
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