Key result
Histone deacetylase inhibitors decreased VEGF secretion, reduced cellular proliferation, and increased apoptosis in non-small-cell lung cancer cells, alongside downregulation of Neuropilin receptors.
Why the study?
Do histone deacetylase inhibitors (HDACi) affect VEGF receptor regulation and cell survival in non-small-cell lung cancer cells?
Do histone deacetylase inhibitors (HDACi) affect VEGF receptor regulation and cell survival in non-small-cell lung cancer cells?
Epigenetic targeting of Neuropilin receptors with HDAC inhibitors may offer a potential therapeutic approach for non-small-cell lung cancer by decreasing cell proliferation and increasing apoptosis.
AIMS: To evaluate the potential therapeutic utility of histone deacetylase inhibitors (HDACi) in targeting VEGF receptors in non-small-cell lung cancer. MATERIALS & METHODS: Non-small-cell lung cancer cells were screened for the VEGF receptors at the mRNA and protein levels, while cellular responses to various HDACi were examined. RESULTS: Significant effects on the regulation of the VEGF receptors were observed in response to HDACi. These were associated with decreased secretion of VEGF, decreased cellular proliferation and increased apoptosis which could not be rescued by addition of exogenous recombinant VEGF. Direct remodeling of the VEGFR1 and VEGFR2 promoters was observed. In contrast, HDACi treatments resulted in significant downregulation of the Neuropilin receptors. CONCLUSION: Epigenetic targeting of the Neuropilin receptors may offer an effective treatment for lung cancer patients in the clinical setting.
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Barr et al. (2015) studied Non-small-cell lung cancer. Histone deacetylase inhibitors (HDACi) was evaluated on Regulation of VEGF receptors, cellular proliferation, and apoptosis. Histone deacetylase inhibitors decreased VEGF secretion, reduced cellular proliferation, and increased apoptosis in non-small-cell lung cancer cells, alongside downregulation of Neuropilin receptors.
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