Key result
Genetic heritability of left ventricular mass was significant at 0.268 (P < 0.0001), and the inheritance mode was compatible with major gene effects in a Chinese population.
Cross-Sectional (n=1,145)
No
Effect estimate: h2 0.268
p-value: p=<0.0001
Left ventricular mass exhibits significant heritability and major gene effects in the Chinese population, with strong parent-son correlations.
Supports genetic evaluation of LV mass in Chinese families; leaves open gene identification and clinical translation.
BACKGROUND: Genetic components controlling for echocardiographically determined left ventricular (LV) mass are still unclear in the Chinese population. METHODS: We conducted a family study from the Chin-San community, Taiwan, and a total of 368 families, 1145 subjects, were recruited to undergo echocardiography to measure LV mass. Commingling analysis, familial correlation, and complex segregation analysis were applied to detect component distributions and the mode of inheritance. RESULTS: The two-component distribution model was the best-fitting model to describe the distribution of LV mass. The highest familial correlation coefficients were mother-son (0.379, P < .0001) and father-son (0.356, P < .0001). Genetic heritability (h2) of LV mass was estimated as 0.268 +/- 0.061 (P < .0001); it decreased to 0.153 +/- 0.052 (P = .0009) after systolic blood pressure adjustment. Major gene effects with polygenic components were the best-fitting model to explain the inheritance mode of LV mass. The estimated allele frequency of the gene was 0.089. CONCLUSION: There were significant familial correlations, heritability and a major gene effect on LV mass in the population-based families.
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Chien et al. (2006) conducted a cross-sectional in Left ventricular mass (n=1,145). Genetic heritability and major gene effects was evaluated on Genetic heritability (h2) of left ventricular mass (h2 0.268, p=<0.0001). Genetic heritability of left ventricular mass was significant at 0.268 (P < 0.0001), and the inheritance mode was compatible with major gene effects in a Chinese population.
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