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March 1, 2003European Heart Journal

The genetic determination of left ventricular mass in healthy adults

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Population

110 twin pairs (220 healthy adults), mean age 55.9+/-10.9 years

Design

Cross-sectional

Authors

LSLorna Swan

Discussion

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Overview

Supports substantial genetic influence on left ventricular mass; leaves open specific loci and requires prospective replication before clinical consideration.

Structured PICO

P
Population
110 twin pairs (220 healthy adults), mean age 55.9+/-10.9 years
O
Outcome
Heritability of left ventricular mass and its association with G-protein beta-3, aldosterone synthase, and beta-1 adrenoceptor genessurrogate

Left ventricular mass has a significant genetic determination in healthy adults, with a heritability estimate of 0.69.

Cite This Study

Lorna Swan (2003) studied this question.

synapsesocial.com/papers/6a6fd17f6c240de38cdb9743https://doi.org/10.1016/s0195-668x(02)00524-9
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