Key result
Genetics explain ~84% of LV mass variance and strongly influence papillary muscle mass in twins.
Why the study?
Earlier twin studies using echocardiography showed genetic variance on heart size, but CMR is more precise and reproducible, and no genetic reports exist on papillary muscle mass.
Does cardiovascular magnetic resonance imaging allow for precise heritability assessment of left ventricular and papillary muscle mass in healthy twins?
Population
25 healthy twin pairs
Design
Twin study
Authors
Loading...
CMR-derived high heritability of LV mass in twins supports genetic dominance; leaves open validation in larger cohorts before informing cardiomyopathy risk models.
Observational (n=50)
Does cardiovascular magnetic resonance imaging allow for precise heritability assessment of left ventricular and papillary muscle mass in healthy twins?
Effect estimate: h2 = 84% for LV mass; h2 = 82% for papillary muscle mass
CMR provides highly precise heritability estimates for left ventricular and papillary muscle mass, revealing significant shared and specific genetic influences even in small cohorts.
Busjahn et al. (2009) conducted an observational in Healthy (n=50). Genetic factors (heritability) was evaluated on Heritability of left ventricular mass and papillary muscle mass (h2 = 84% for LV mass; h2 = 82% for papillary muscle mass). Genetic factors strongly influenced left ventricular mass (h2 = 84%) and papillary muscle mass (h2 = 82%) as assessed by cardiac magnetic resonance imaging in healthy twins.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: