Key result
Novel genetic effects accounted for 32-41% of the phenotypic variance in left ventricular wall thickness at 4.1-year follow-up, with substantial heritability in both African and European Americans.
Population
517 European-American and African-American twin pairs at visit 1 and 422 EA and AA twin pairs at follow-up…
Design
Cohort
Follow-up
4.1 years
Authors
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Should not yet change adolescent cardiac screening; leaves open whether novel genetic effects on LV wall thickness predict adult outcomes.
Cohort (n=1,034)
The study demonstrates substantial heritability of cardiac structure in both African-American and European-American adolescents, with novel genetic influences emerging during the transition to adulthood.
Kapuku et al. (2008) conducted a cohort in Left ventricular structure (n=1,034). Genetic factors was evaluated on Heritability and novel genetic effects on left ventricular structure. Novel genetic effects accounted for 32-41% of the phenotypic variance in left ventricular wall thickness at 4.1-year follow-up, with substantial heritability in both African and European Americans.
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