Key result
LMWH combined with intermittent pneumatic compression eliminated deep-vein thrombosis compared to a 28.6% prevalence with LMWH and graduated compression stockings (p<0.0001).
Why the study?
Does enoxaparin combined with intermittent pneumatic compression prevent deep-vein thrombosis compared to enoxaparin with graduated compression stockings in patients undergoing primary unilateral THR or TKR?
Population
131 patients undergoing primary unilateral total hip replacement (THR) or total knee replacement (TKR)
Comparison
Enoxaparin 40 mg daily combined with… vs Enoxaparin 40 mg daily combined with graduated…
Design
RCT, randomised
Follow-up
early post-operative phase
Authors
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Supports LMWH plus IPC over LMWH plus GCS for DVT prevention after THR/TKR; extends evidence for optimized mechanical-pharmacologic prophylaxis.
RCT (n=131)
Does enoxaparin combined with intermittent pneumatic compression prevent deep-vein thrombosis compared to enoxaparin with graduated compression stockings in patients undergoing primary unilateral THR or TKR?
Absolute Event Rate: 0% vs 28.6%
p-value: p=<0.0001
Combined prophylaxis with LMWH and intermittent pneumatic compression is significantly more effective than LMWH with graduated compression stockings for preventing DVT after THR and TKR.
Silbersack et al. (2004) conducted an RCT in Total hip or knee replacement (n=131). LMWH and intermittent pneumatic compression vs. LMWH and graduated compression stockings was evaluated on Deep-vein thrombosis detected by compression ultrasonography (p=<0.0001). LMWH combined with intermittent pneumatic compression eliminated deep-vein thrombosis compared to a 28.6% prevalence with LMWH and graduated compression stockings (p<0.0001).
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