Why the study?
Does intermittent mechanical compression combined with pharmacological thromboprophylaxis reduce deep-vein thrombosis and pulmonary embolism in patients undergoing hip or knee replacement compared to either modality alone?
Population
1,399 patients undergoing hip or knee replacement across 6 randomized controlled trials
Comparison
Intermittent mechanical compression combined… vs Mechanical compression alone or pharmacological…
Design
Meta-analysis
Authors
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Supports adding mechanical compression to anticoagulation for DVT prevention after hip or knee arthroplasty; strengthens Level 1 evidence for guideline recommendations.
Does intermittent mechanical compression combined with pharmacological thromboprophylaxis reduce deep-vein thrombosis and pulmonary embolism in patients undergoing hip or knee replacement compared to either modality alone?
Combining intermittent mechanical compression with pharmacological prophylaxis significantly reduces the risk of deep-vein thrombosis in patients undergoing hip or knee replacement compared to anticoagulation alone.
Kakkos et al. (2012) studied this question.
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