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April 1, 2000Tropical Medicine & International HealthOpen Access

Congenital transmission of Trypanosoma cruzi: an operational outline for detecting and treating infected infants in north‐western Argentina

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Key result

A province-wide screening programme detected T. cruzi in 5.5% of pregnant women and congenital infection in 7.1% of their infants, with 30 of 32 treated infants remaining parasitologically negative.

Why the study?

Does a province-wide screening and treatment program effectively detect and cure congenital T. cruzi infection in infants?

Population

16,842 pregnant women and their newborns in Tucumán, north-western Argentina.

Design

Cohort

Follow-up

1 year

Authors

SBSonia Bartolomé BlancoUniversity of Buenos AiresESElsa L. SeguraConsejo Nacional de Investigaciones Científicas y TécnicasECE. CuraAdministración Nacional de Laboratorios e Institutos de Salud

Discussion

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Implication

Suggests province-wide screening may detect and treat congenital Chagas; hypothesis-generating pending controlled trials.

Study Design

Type

Observational (n=16,842)

Multicenter

Yes

Structured PICO

Does a province-wide screening and treatment program effectively detect and cure congenital T. cruzi infection in infants?

P
Population
16,842 pregnant women screened for T. cruzi, with 315 newborns of seroreactive mothers followed during their first year of life to detect and treat congenital infection.
E
Exposure
Province-wide screening program consisting of routine screening of pregnant women for T. cruzi seroreactivity, serological and parasitological follow-up of newborns during the first year of life, and treatment of infected infants with nifurtimox or benznidazole.
O
Outcome
Detection of congenital T. cruzi infection and parasitological/serological negativity after treatment.surrogate

A province-wide screening program at the primary care level is feasible and effective for detecting and successfully treating congenital T. cruzi infections.

Cite This Study

Blanco et al. (2000) conducted an observational in Congenital Trypanosoma cruzi infection (n=16,842). Routine screening of pregnant women and follow-up/treatment of newborns was evaluated on Congenital T. cruzi infection in infants born to seroreactive women. A province-wide screening programme detected T. cruzi in 5.5% of pregnant women and congenital infection in 7.1% of their infants, with 30 of 32 treated infants remaining parasitologically negative.

synapsesocial.com/papers/6a95877f7ee17f80122cbfc6https://doi.org/10.1046/j.1365-3156.2000.00548.x
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Fetal IgG specificities against Trypanosoma cruzi antigens in infected newborns.1990 · 89 citations
  2. 2Diagnostic Value of Detecting Specific IgA and IgM with Recombinant Trypanosoma cruzi Antigens in Congenital Chagas' Disease1995 · 34 citations
  3. 3Direct micromethod for diagnosis of acute and congenital Chagas' disease1983 · 176 citations
  4. 4Quality assurance of the serologic diagnosis of Chagas' disease1998 · 19 citations