Key result
No single best diagnostic approach exists for PRRSV; the choice of specimen and test must be tailored to the specific testing objective, often requiring multiple assays or specimen types.
Why the study?
Broad issues affect test performance for agents producing persistent infections, necessitating an understanding of the relationship between disease transition stages and diagnostic transition stages using PRRSV as an example.
Meta-Analysis (n=4,307)
Effective PRRSV diagnosis requires tailoring the choice of specimen and test to specific objectives, often utilizing multiple assays.
Answers are grounded in this paper and cite their sources.
Swine veterinarians must tailor PRRSV testing to specific objectives; reinforces meta-analytic support for multi-assay strategies over uniform protocols.
Herein we review broad issues that affect test performance for agents that produce persistent infections. Using PRRSV as an example, the relationship between "disease transition stages" and "diagnostic transition stages" is discussed using meta-analyses of diagnostic data (n = 4307 results) from the refereed literature to highlight the key issues. Although diagnostic technology will continue to improve, it may be concluded from the analysis that there can be no single best diagnostic approach; rather, the choice of specimen and test must be tailored to the specific testing objective. In most cases, meeting the testing objective(s) will require the use of more than one assay and/or specimen type.
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Henao-Díaz et al. (2020) conducted a meta-analysis in PRRSV (persistent infections) (n=4,307). PRRSV diagnostics was evaluated on Test performance. No single best diagnostic approach exists for PRRSV; the choice of specimen and test must be tailored to the specific testing objective, often requiring multiple assays or specimen types.
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