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Two studies have recently reported normal aminotransferase concentrations in patients with antibodies to hepatitis C virus and histologically proved chronic liver disease.1,2 These studies, however, disagreed about the predictive values of concentrations of hepatitis C virus RNA in detecting liver disease. Tests for hepatitis C virus are now included in screening tests for blood donors and in health check ups in Italy, and the number of patients with antibodies to hepatitis C virus and normal aminotransferase concentrations referred to outpatient clinics is rising sharply. We conducted a study to determine the prevalence of histological liver disease in these patients and its relation …
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Bruno et al. (1994) studied this question.
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