Key result
Transcatheter aortic valve implantation in 171 patients improved quality of life metrics but resulted in deterioration in 10-m walk test and handgrip strength at 1 month and 1 year.
Why the study?
Although frailty measures have been used to predict outcomes after TAVI, few studies have evaluated changes in these measures.
Does transcatheter aortic valve implantation (TAVI) improve frailty and quality of life in high-risk patients with severe aortic stenosis?
Observational (n=171)
Does transcatheter aortic valve implantation (TAVI) improve frailty and quality of life in high-risk patients with severe aortic stenosis?
TAVI improves quality of life but does not reverse objective measures of frailty at 1 year in high-risk patients with severe aortic stenosis.
TAVI was associated with improved quality of life but not objective frailty reversal; leaves open whether frailty should guide selection in high-risk aortic stenosis.
BACKGROUND: Transcatheter aortic valve implantation (TAVI) is an effective alternative to surgical valve replacement in high-risk patients with severe aortic stenosis. Although measures of frailty have been used to attempt to predict outcomes in this population, few studies have demonstrated changes in these measures. METHODS: We performed a prospective, observational study of 171 patients undergoing TAVI, of whom 44 had maximal follow-up of 1 month and 50 had maximal follow-up of 1 year. Quality of life was assessed using the Minnesota Living With Heart Failure Questionnaire, Katz Index of Independence in Activities of Daily Living questionnaire, and patient perception of overall well-being. Frailty was measured using the 10-m walk test and handgrip strength testing. RESULTS: In the overall cohort, participants demonstrated improvements in quality of life metrics, but deterioration in 10-m walk test and handgrip at 1 month. These trends continued at 1 year. However, patients in the lowest quintile of handgrip and 10-m walk test demonstrated a trend of improvements in these metrics during follow-up. CONCLUSIONS: Despite improvements in quality of life after TAVI, no improvements in frailty were observed in patients at 1 year.
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Gouda et al. (2020) conducted an observational in severe aortic stenosis (n=171). Transcatheter aortic valve implantation (TAVI) was evaluated on Quality of life and frailty (10-m walk test and handgrip strength). Transcatheter aortic valve implantation in 171 patients improved quality of life metrics but resulted in deterioration in 10-m walk test and handgrip strength at 1 month and 1 year.
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