Key result
A high SYNTAX score was associated with a significantly increased risk of developing diabetes mellitus compared to a low score (HR 30; 95% CI 9-105; p<0.0001).
Why the study?
Whether an increased incidence of diabetes mellitus is related to the severity of coronary atherosclerosis was unknown.
Does the severity of coronary atherosclerosis (SYNTAX score) predict the onset of diabetes mellitus in non-diabetic patients referred for coronary angiography?
Cohort (n=570)
Does the severity of coronary atherosclerosis (SYNTAX score) predict the onset of diabetes mellitus in non-diabetic patients referred for coronary angiography?
Answers are grounded in this paper and cite their sources.
The severity of coronary atherosclerosis, as measured by the SYNTAX score, is a strong independent predictor of incident diabetes mellitus in patients undergoing coronary angiography.
Background: Cardio-vascular target organ damage predicts the onset of type 2 diabetes mellitus (DM) in hypertensive patients. Whether an increased incidence of DM is also in relation to the severity of coronary atherosclerosis is unknown. Objective: We evaluated the onset of DM in relation to the extent and severity of coronary atherosclerosis, using the SYNTAX (Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery) score (SS), in patients with stable angina or acute coronary syndromes, referred for coronary angiography (CA). Methods: Non-diabetic patients that underwent CA for the first time were included, and the SS was computed. Predictors of DM onset in low, medium, and high SSs were investigated. Results: Five hundred and seventy patients were included, and the mean SS was 6.3 ± 7.6. During a median follow-up of 79 months (interquartile range (IQR): 67–94), 74 patients (13%) developed DM. The risk of DM onset was significantly higher in the patients with a medium or high SS (hazard ratio (HR)—95% confidence interval (CI): 16 (4–61), p < 0.0001; and 30 (9–105), p < 0.0001, vs low SS, respectively), even after adjustment for obesity, history of hypertension, impaired fasting glucose, and cardiovascular therapy. Conclusions: The severity and extent of the coronary atherosclerosis, evaluated by the SS, is a strong and independent predictor of the development of DM in patients, referred to CA.
No takes yet. Share an insight, caveat, or question.
Colaiori et al. (2019) conducted a cohort in Stable angina or acute coronary syndromes (n=570). High SYNTAX score (severe coronary atherosclerosis) vs. Low SYNTAX score was evaluated on Onset of diabetes mellitus (HR 30, 95% CI 9-105, p=<0.0001). A high SYNTAX score was associated with a significantly increased risk of developing diabetes mellitus compared to a low score (HR 30; 95% CI 9-105; p<0.0001).
Synapse has enriched 10 related papers. Consider them for comparative context: