July 1, 2016European Journal of Heart Failure
Iron Deficiency and Risk of Early Readmission Following Hospitalization for Acute Heart Failure. Reply
Key result
Absolute iron deficiency (ferritin <100 µg/L), but not functional iron deficiency, was independently associated with a higher risk of 30-day readmission in patients with acute heart failure.
Population
Patients with acute heart failure (AHF)
Design
Editorial
Follow-up
30-day
Authors
Discussion
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Implication
In patients with acute heart failure, absolute iron deficiency is highly prevalent and independently associated with an increased risk of early 30-day readmission.
Structured PICO
P
Population
Patients with acute heart failure (AHF)
O
Outcome
30-day readmissionhard clinical
In patients with acute heart failure, absolute iron deficiency is highly prevalent and independently associated with an increased risk of early 30-day readmission.
Limitations
- Traditional iron biomarkers (serum ferritin and TSAT) underestimate iron deficiency in the presence of high inflammatory activity and renal dysfunction.
- The reason why absolute iron deficiency, but not functional iron deficiency, was related to the risk of early adverse outcomes cannot be explored with the available data.
- Serum ferritin and TSAT have limitations in assessing iron homeostasis, particularly in patients with high inflammatory activity and renal dysfunction
- Traditional iron biomarkers underestimate iron deficiency in the presence of confounding situations
Cite This Study
Núñez et al. (2016) conducted a letter in Acute heart failure. Absolute iron deficiency (ferritin <100 µg/L) vs. Functional iron deficiency was evaluated on 30-day readmission. Absolute iron deficiency (ferritin <100 µg/L), but not functional iron deficiency, was independently associated with a higher risk of 30-day readmission in patients with acute heart failure.