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January 26, 2018Nephrology Dialysis TransplantationOpen Access

In patients with chronic kidney disease, diabetes with moderate proteinuria (0.15-0.49 g/day) was associated with a higher risk of mortality (HR 1.92; 95% CI 1.25-2.95).

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Why the study?

Does the extent of proteinuria dictate the cardiorenal prognosis in patients with coexisting diabetes mellitus and chronic kidney disease?

Population

2,174 patients with chronic kidney disease treated with drugs inhibiting the renin-angiotensin system…

Comparison

Diabetes mellitus stratified by residual… vs Non-diabetic chronic kidney disease stratified…

Design

Cohort

Follow-up

4.07 years

Key result

In patients with chronic kidney disease, diabetes with moderate proteinuria (0.15-0.49 g/day) was associated with a higher risk of mortality (HR 1.92; 95% CI 1.25-2.95).

Authors

RMRoberto MinutoloFGFrancis B. GabbaiMPMichele Provenzano

Discussion

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Member takes

Overview

Moderate proteinuria flags higher mortality risk in diabetic CKD; extends prognostic observations but should not yet change practice.

Study Design

Type

Cohort (n=2,174)

Multicenter

Yes

Structured PICO

Does the extent of proteinuria dictate the cardiorenal prognosis in patients with coexisting diabetes mellitus and chronic kidney disease?

P
Population
2,174 chronic kidney disease patients treated with renin-angiotensin system inhibitors, with and without diabetes, followed for 4.07 years.
E
Exposure
Diabetes mellitus stratified by residual proteinuria level (<0.15, 0.15-0.49, 0.5-1 and >1 g/day)
C
Comparator
Non-diabetic chronic kidney disease stratified by residual proteinuria level
O
Outcome
All-cause mortality, fatal and non-fatal cardiovascular (CV) events, and end-stage renal disease (ESRD)hard clinical

Main Result

Hazard Ratio: 1.92 (95% CI 1.25–2.95)

In patients with chronic kidney disease, the excess cardiorenal risk associated with diabetes is largely driven by the presence of proteinuria, as non-proteinuric diabetic patients have similar risks to non-diabetic patients.

Cite This Study

Minutolo et al. (2018) conducted a cohort in Chronic kidney disease with or without diabetes mellitus (n=2,174). Proteinuria and diabetes mellitus vs. Non-proteinuric (<0.15 g/day) or non-diabetic patients was evaluated on All-cause mortality (HR 1.92, 95% CI 1.25-2.95). In patients with chronic kidney disease, diabetes with moderate proteinuria (0.15-0.49 g/day) was associated with a higher risk of mortality (HR 1.92; 95% CI 1.25-2.95).

synapsesocial.com/papers/6a959b1cd002db7cabf5a4a2https://doi.org/10.1093/ndt/gfy032
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prognostic impact of proteinuria in diabetic patients without chronic kidney disease undergoing percutaneous coronary intervention2025
  2. 2Major adverse cardiovascular events in people with chronic kidney disease in relation to disease severity and diabetes status2019 · 57 citations
  3. 3Low-grade proteinuria and atherosclerotic cardiovascular disease: A transition study of patients with diabetic kidney disease2022 · 3 citations
  4. 4The number of nephroprotection targets attained is associated with cardiorenal outcomes and mortality in patients with diabetic kidney disease. The <scp>CKD‐REIN</scp> cohort study2024 · 3 citations
  5. 5Impact of chronic kidney disease and end-stage renal disease on the mid-term adverse outcomes in diabetic patients with cardiovascular diseases2024 · 5 citations