Why the study?
Does the apoC-III (Gln38-->Lys) variant increase plasma triglyceride levels in humans?
Does the apoC-III (Gln38-->Lys) variant increase plasma triglyceride levels in humans?
The identification of the apoC-III (Gln38-->Lys) variant and its association with elevated triglycerides supports the role of apoC-III in regulating the catabolism of triglyceride-rich lipoproteins.
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The apoC-III variant was associated with higher triglycerides; supports its regulatory role but leaves clinical relevance and outcomes open.
Pullinger et al. (1997) studied this question.
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