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February 23, 2004Nucleic Acids ResearchOpen Access

Identification of cellular proteins enhancing activities of internal ribosomal entry sites by competition with oligodeoxynucleotides

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Population

in vitro translation system with polioviral and rhinoviral IRES elements

Design

Preclinical

Authors

KCKyung H. Choi

Discussion

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Overview

Hypothesis-generating for IRES-targeted antivirals; leaves open relevance to human viral infections.

Structured PICO

P
Population
in vitro translation system with polioviral and rhinoviral IRES elements
I
Intervention
strategy involving oligodeoxynucleotides, MALDI-TOF MS, and depletion/repletion to identify ITAFs
O
Outcome
identification of proteins enhancing IRES-dependent translation

A novel strategy successfully identified poly(rC)-binding proteins 1 and 2 as enhancers of IRES-dependent translation.

Cite This Study

Kyung H. Choi (2004) studied this question.

synapsesocial.com/papers/6a959bf718385f2ccae3d847https://doi.org/10.1093/nar/gkh300
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