Key result
ALS patients showed a significant reduction in centrally mediated sympathetic vasoconstrictor response and higher mean arterial blood pressure during tilt testing compared with age-matched controls.
Why the study?
Do patients with ALS have impaired centrally and peripherally mediated autonomic vascular reflexes compared to age-matched controls?
Population
9 patients with Amyotrophic lateral sclerosis (ALS) and 15 age-matched controls
Comparison
Evaluation of centrally and peripherally… vs Age-matched controls
Design
Case-control
Authors
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ALS patients may exhibit central sympathetic dysfunction on tilt testing without changing management; leaves open clinical impact and needs prospective validation.
Case-Control (n=24)
Do patients with ALS have impaired centrally and peripherally mediated autonomic vascular reflexes compared to age-matched controls?
ALS is associated with abnormalities consistent with a solely centrally located sympathetic dysfunction, which appears independent of the stage of the disease.
Karlsborg et al. (2003) conducted a case-control in Amyotrophic lateral sclerosis (ALS) (n=24). Amyotrophic lateral sclerosis (ALS) vs. Age-matched controls was evaluated on Centrally and peripherally mediated autonomic vascular reflexes. ALS patients showed a significant reduction in centrally mediated sympathetic vasoconstrictor response and higher mean arterial blood pressure during tilt testing compared with age-matched controls.
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