What is the clinical evidence from this study?

Study design: Cohort. Population: Stage B heart failure. Intervention: Low physical activity vs. High physical activity. Primary outcome: Composite of all-cause death, myocardial infarction hospitalization, and HF hospitalization (p== 0.01).

What question did this study set out to answer?

To investigate the association between physical activity levels, physical function, and 2-year clinical outcomes in older patients with Stage B heart failure.

August 18, 2026International Journal of Cardiology Cardiovascular Risk and PreventionOpen Access

Lower physical activity is linked to adverse cardiovascular events and impaired function in Stage B HF.

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Why the study?

Physical activity is a key modifiable lifestyle factor linked to cardiovascular outcomes, but its clinical significance in Stage B heart failure remains unclear.

Does higher physical activity improve long-term outcomes and physical function in older patients with Stage B heart failure?

Population

Older patients with Stage B heart failure from the PAPRIKA-HF registry

Comparison

High vs low physical activity based on median IPAQ score

Design

Sub-analysis of a multicenter registry

Follow-up

2-year

Key result

Lower physical activity was independently associated with adverse cardiovascular outcomes and impaired physical function in older patients with Stage B heart failure (P=0.01).

Authors

HTHiroyuki TsukaharaKindai University Sakai Hospital KMKoichiro MatsumuraHeart Failure / Cardiomyopathy SMShun MorishitaMorishita Jintan (Japan)

Discussion

Member takes

Overview

Low activity flags higher risk in Stage B HF; leaves open whether increasing activity improves outcomes.

Key Points

To investigate the association between physical activity levels, physical function, and 2-year clinical outcomes in older patients with Stage B heart failure.
Analyzed data from the multicenter PAPRIKA-HF registry, assessing physical activity through the International Physical Activity Questionnaire (IPAQ).
Stratified patients into high and low physical activity cohorts based on the median IPAQ score.
Tracked a 2-year composite primary outcome consisting of all-cause death, myocardial infarction hospitalization, and heart failure hospitalization.
Low physical activity was independently associated with an increased incidence of the composite primary outcome of all-cause death, myocardial infarction, or heart failure hospitalization (p = 0.01).
Patients with low physical activity demonstrated significantly reduced skeletal muscle mass, diminished handgrip strength, and slower gait speed compared to active counterparts.

Study Design

Type

Cohort

Multicenter

Yes

Structured PICO

Does higher physical activity improve long-term outcomes and physical function in older patients with Stage B heart failure?

Population

Older patients with Stage B heart failure from a multicenter registry, followed for 2 years.

Exposure

High physical activity (categorized by median International Physical Activity Questionnaire [IPAQ] score)

Comparator

Low physical activity (categorized by median IPAQ score)

Outcome

Composite of all-cause death, myocardial infarction hospitalization, and HF hospitalization during 2-year follow-upcomposite

Main Result

p-value: p== 0.01

Lower physical activity in older patients with Stage B heart failure is associated with worse cardiovascular outcomes and impaired physical function, suggesting it may help identify high-risk individuals before symptomatic HF develops.

Cite This Study

Tsukahara et al. (2026) conducted a cohort in Stage B heart failure. Low physical activity vs. High physical activity was evaluated on Composite of all-cause death, myocardial infarction hospitalization, and HF hospitalization (p== 0.01). Lower physical activity was independently associated with adverse cardiovascular outcomes and impaired physical function in older patients with Stage B heart failure (P=0.01).

synapsesocial.com/papers/6a959f8693232d20934bc9fd https://doi.org/10.1016/j.ijcrp.2026.200700

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August 18, 2026International Journal of Cardiology Cardiovascular Risk and PreventionOpen Access

Lower physical activity is linked to adverse cardiovascular events and impaired function in Stage B HF.

View Full Paper

Ask AI

Bookmark

Why the study?

Physical activity is a key modifiable lifestyle factor linked to cardiovascular outcomes, but its clinical significance in Stage B heart failure remains unclear.

Does higher physical activity improve long-term outcomes and physical function in older patients with Stage B heart failure?

Population

Older patients with Stage B heart failure from the PAPRIKA-HF registry

Comparison

High vs low physical activity based on median IPAQ score

Design

Sub-analysis of a multicenter registry

Follow-up

2-year

Key result

Lower physical activity was independently associated with adverse cardiovascular outcomes and impaired physical function in older patients with Stage B heart failure (P=0.01).

Authors

HTHiroyuki TsukaharaKindai University Sakai Hospital KMKoichiro MatsumuraHeart Failure / Cardiomyopathy SMShun MorishitaMorishita Jintan (Japan)

Discussion

Member takes

Overview

Low activity flags higher risk in Stage B HF; leaves open whether increasing activity improves outcomes.

Key Points

To investigate the association between physical activity levels, physical function, and 2-year clinical outcomes in older patients with Stage B heart failure.
Analyzed data from the multicenter PAPRIKA-HF registry, assessing physical activity through the International Physical Activity Questionnaire (IPAQ).
Stratified patients into high and low physical activity cohorts based on the median IPAQ score.
Tracked a 2-year composite primary outcome consisting of all-cause death, myocardial infarction hospitalization, and heart failure hospitalization.
Low physical activity was independently associated with an increased incidence of the composite primary outcome of all-cause death, myocardial infarction, or heart failure hospitalization (p = 0.01).
Patients with low physical activity demonstrated significantly reduced skeletal muscle mass, diminished handgrip strength, and slower gait speed compared to active counterparts.

Study Design

Type

Cohort

Multicenter

Yes

Structured PICO

Does higher physical activity improve long-term outcomes and physical function in older patients with Stage B heart failure?

Population

Older patients with Stage B heart failure from a multicenter registry, followed for 2 years.

Exposure

High physical activity (categorized by median International Physical Activity Questionnaire [IPAQ] score)

Comparator

Low physical activity (categorized by median IPAQ score)

Outcome

Composite of all-cause death, myocardial infarction hospitalization, and HF hospitalization during 2-year follow-upcomposite

Main Result

p-value: p== 0.01

Cite This Study

synapsesocial.com/papers/6a959f8693232d20934bc9fd https://doi.org/10.1016/j.ijcrp.2026.200700

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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