Key result
Application of neuregulin-1beta to quiescent rat cardiocytes induced expressional reprogramming, including a 50-100% increase in transcripts of multiple redox systems and hypertrophy pathways.
Population
Freshly isolated adult primary rat cardiocytes (n=6)
Comparison
Recombinant human neuregulin-1beta for 24 h vs Control cardiocytes
Design
Preclinical
Follow-up
24 h
Authors
Loading...
No immediate clinical implications; leaves open whether neuregulin-1beta reprogramming translates to human cardiocytes.
Neuregulin-1beta promotes survival and protective pathways in adult rat cardiocytes through MAPK-dependent upregulation of oxidative defense and hypertrophy genes.
Giraud et al. (2005) studied Freshly isolated adult primary rat cardiocytes (n=6). recombinant human neuregulin-1beta (NRG-1beta) vs. control cardiocytes was evaluated on Transcript level alterations. Application of neuregulin-1beta to quiescent rat cardiocytes induced expressional reprogramming, including a 50-100% increase in transcripts of multiple redox systems and hypertrophy pathways.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: