Why the study?
Does 9c,11t-CLA enriched oil (CLA80:20) reduce platelet function and inflammation in healthy adults at low to moderate cardiovascular risk?
Population
43 healthy adults at low to moderate risk of cardiovascular disease
Comparison
9c,11t-CLA enriched oil 4 g/day for two weeks vs Placebo for two weeks (cross-over design)
Design
RCT, randomized, baseline-controlled cross-over
Follow-up
two weeks per phase
Key result
Supplementation with 4 g/day of CLA80:20 had no significant effect on platelet function compared with placebo, though TRAP-induced P-selectin expression was higher after supplementation (p=0.017).
Authors
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No platelet benefit from 4 g/day CLA80:20 in low-moderate risk adults; challenges hypothesized antiplatelet effects and extends null evidence for this isomer.
RCT (n=43)
cross-over
Does 9c,11t-CLA enriched oil (CLA80:20) reduce platelet function and inflammation in healthy adults at low to moderate cardiovascular risk?
Dietary supplementation with 9c,11t-CLA enriched oil does not significantly affect platelet function or inflammation in healthy adults at low to moderate cardiovascular risk.
Bachmair et al. (2015) conducted an RCT in healthy adults at low to moderate risk of cardiovascular disease (n=43). 9c,11t-CLA enriched oil (CLA80:20) vs. placebo was evaluated on platelet function measured by Platelet Function Analyzer-100. Supplementation with 4 g/day of CLA80:20 had no significant effect on platelet function compared with placebo, though TRAP-induced P-selectin expression was higher after supplementation (p=0.017).
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