Emergency Treatment of Barbiturate Intoxication With Hemodialysis

Case Reports1 May 1957EMERGENCY TREATMENT OF BARBITURATE INTOXICATION WITH HEMODIALYSISJOSEPH C. PENDER, RICHARD T. BEEBE, F.A.C.P., JOHN J. GARRETT, JOHN E. KILEYJOSEPH C. PENDERSearch for more papers by this author, RICHARD T. BEEBE, F.A.C.P.Search for more papers by this author, JOHN J. GARRETTSearch for more papers by this author, JOHN E. KILEYSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-46-5-997 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBarbiturate intoxication is an important cause of morbidity and mortality. The following case report describes a severe case of barbiturate intoxication in which hemodialysis, as recently recommended by Kyle2 and Alwall,1 was applied. Since we have noted reports of only five patients with barbiturate intoxication1-4 treated by hemodialysis, the striking clinical changes in a patient during hemodialysis prompted a report of this case.CASE REPORTA 63 year old white married woman was admitted to the Albany Hospital Emergency Room in coma at 5:00 p.m. Her husband related that the patient had been moody and depressed for the previous four...Bibliography1. AlwallLindgrenLunderquist NPA: On the artificial kidney. XX. Treatment of severe phenobarbital poisoning in rabbits by means of forced polyuria, exchange ultrafiltration and dialysis, and a preliminary report on dialytic treatment of barbiturate poisoning in patients, Acta med. Scandinav. 143: 288, 1952. CrossrefMedlineGoogle Scholar2. KyleJeghersWalshDoolanWishinskyPallotta LHHWPPDHA: The application of hemodialysis to the treatment of barbiturate poisoning, J. Clin. Investigation 32: 364, 1953. CrossrefMedlineGoogle Scholar3. Editorial: Hemodialysis in the therapy of barbiturate intoxication, J. A. M. A. 152: 822 (June 27) 1953. CrossrefMedlineGoogle Scholar4. BrownAnsellSchiele IAASBC: The use of hemodialysis in the treatment of barbiturate intoxication, Minnesota Med. 37: 650, 1954. MedlineGoogle Scholar5. Goldbaum LR: Analytical determination of barbiturates, Anal. Chem. 24: 1604, 1952. CrossrefGoogle Scholar6. FisherFreimuth RSHC: Barbiturates, Postgrad. Med. 17: A28, 1955. MedlineGoogle Scholar7. SunshineHackett IER: Barbiturate studies. II. Correlation between clinical condition and blood barbiturate levels, Am. J. Clin. Path. 24: 1133, 1954. CrossrefMedlineGoogle Scholar8. ReedDriggsFoote CEMFCC: Acute barbiturate intoxication: a study of 300 cases based on a physiologic system of classification of the severity of the intoxication, Ann. Int. Med. 37: 290, 1952. LinkGoogle Scholar9. SunshineLeonards IJR: Use of artificial kidney for removal of barbiturates in dogs, Proc. Soc. Exper. Biol. and Med. 86: 638, 1954. CrossrefMedlineGoogle Scholar10. JonesDooleyMurphy AWJJR: Treatment of choice in barbiturate poisoning, J. A. M. A. 143: 884, 1950. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication March 21, 1956.From the Medical Department, Albany Medical College and Albany Hospital, Albany, N. Y.Requests for reprints should be addressed to John E. Kiley, M.D., Department of Medicine, The Albany Medical College of Union University, Albany, N. Y.†We are indebted to the New York State Police Laboratory for the determinations of barbiturate levels included in this report. The method of Goldbaum5 was used. A Tuinal standard was used, and the exact amounts of amobarbital and secobarbital were not determined. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByExtracorporeal Treatment for Barbiturate Poisoning: Recommendations From the EXTRIP WorkgroupAtemregulation bei Barbituratvergiftung und bei Cor pulmonaleIndications for DialysisDie extracorporale Dialyse von LuminalDie Therapie der Schlafmittelvergiftungen 1 May 1957Volume 46, Issue 5Page: 997-1000KeywordsAttentionComaEmergency departmentIngestionIntoxicationMedical dialysisMorbidityMortalityResearch laboratoriesRespiration Issue Published: 1 May 1957 PDF DownloadLoading ...