The incidience and parameters associated with diarrhea related to clindamycin usage were studied in a population of both inpatients and outpatients. Diarrhea occurred in 66 (6.6%) of the 1,000 patients. In three of them, substantial morbidity was associated with the diarrhea. Of the multiple parameters that were evaluated, significant association with diarrhea was found only for age (patients over the age of 20 years) (P less than .01) and sex (females) (P less than .005). Interestingly, dose, duration, and route of administration showed no significant relationship to diarrhea (P greater than .05).
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John Swartzberg (1976) studied this question.