Key result
Opium addiction was not significantly associated with an increased risk of myocardial infarction (OR 1.4, P>0.05) in this case-control study.
Why the study?
Does opium addiction increase the incidence of myocardial infarction?
Case-Control (n=300)
No
Does opium addiction increase the incidence of myocardial infarction?
Odds Ratio: 1.4
Absolute Event Rate: 22% vs 16.6%
p-value: p=>0.05
This case-control study found no significant association between opium addiction and the incidence of myocardial infarction, though traditional risk factors were predictive.
No change to MI risk counseling for opium users; leaves open any causal link pending prospective studies.
Ischemic Heart Disease (IHD) and Myocardial Infarction (MI) are one of the most important disease which cause mortality and morbidity. Opioid peptides and exogenous opioid such as morphine are known to exert an important cardiovascular effect. To study effect of opium addiction to incidence of MI. A Case-Control study was designed in Kerman university. 150 patients with MI was admitted to CCU and 150 matched patients admitted in surgical wards evaluate from cardiovascular risk factor and opium addiction. Analysis of data suggested no difference between two groups (P>0.05). But smoking OR = 2.45, hypertension OR = 2.65, Diabetes mellitus OR = 1.82 and Hypercholesterolemia OR = 3.16 were a risk factor for MI. Effect of opium in IHD has controversial. But recent of study defined that opioid peptides have a cardioprotective effect. Many exact and longitudinal studies should design for this purpose.
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Azimzade-S et al. (2005) conducted a case-control in Myocardial Infarction (n=300). Opium addiction vs. No opium addiction was evaluated on Myocardial Infarction (OR 1.4, p=>0.05). Opium addiction was not significantly associated with an increased risk of myocardial infarction (OR 1.4, P>0.05) in this case-control study.
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