Key result
The triglyceride glucose index effectively identified insulin resistance in Turkish women with polycystic ovary syndrome at an optimal cutoff of 4.44, yielding a sensitivity of 70% and a specificity of 60% (AUC 0.693).
Why the study?
Current gold-standard methods for assessing insulin resistance in PCOS are often impractical for routine clinical use.
Does the triglyceride glucose (TyG) index accurately identify insulin resistance in Turkish women with polycystic ovary syndrome compared to HOMA-IR?
Observational (n=247)
No
Does the triglyceride glucose (TyG) index accurately identify insulin resistance in Turkish women with polycystic ovary syndrome compared to HOMA-IR?
Effect estimate: AUC 0.693
Absolute Event Rate: 70% vs 60%
p-value: p=0.035
The triglyceride glucose (TyG) index offers a practical and cost-effective alternative to HOMA-IR for identifying insulin resistance in women with polycystic ovary syndrome.
May support TyG as a practical IR marker in PCOS; leaves open validation before clinical adoption.
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Helvacı et al. (2025) conducted an observational in Polycystic ovary syndrome (n=247). Triglyceride glucose (TyG) index vs. HOMA-IR was evaluated on Detection of insulin resistance (HOMA-IR ≥2.5) (AUC 0.693, p=0.035). The triglyceride glucose index effectively identified insulin resistance in Turkish women with polycystic ovary syndrome at an optimal cutoff of 4.44, yielding a sensitivity of 70% and a specificity of 60% (AUC 0.693).
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