Why the study?
Does inhalation of 30% carbon dioxide affect peripheral blood flow in human subjects?
Does inhalation of 30% carbon dioxide affect peripheral blood flow in human subjects?
Inhalation of 30% carbon dioxide induces intense peripheral vasoconstriction in human subjects, which is likely deep to the skin and not entirely dependent on nervous mechanisms.
Answers are grounded in this paper and cite their sources.
CO2 inhalation may induce intense peripheral vasoconstriction; leaves open mechanisms and clinical relevance pending modern confirmation.
Inhalation of 30% carbon dioxide for 1 to 2 min. caused a transient increase followed by a marked fall in blood flow through the normal forearm and calf. Since there was an associated large increase in arterial blood pressure, the fall in flow was due to intense vasoconstriction. It is likely that the vasoconstriction in the forearm occurred deep to the skin because the oxygen saturation of the superficial venous blood did not fall during the inhalation. Since there was a slight decrease in flow through the nerve-blocked forearm in spite of the increased blood pressure, it is unlikely that nervous vasoconstriction can completely account for the marked decrease in muscle flow.
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MCARDLE et al. (1957) studied this question.
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