Meaningful Outcome Measures in Cardiac Surgery
Key result
Disability-free survival is proposed as the ideal patient-centered outcome measure for cardiac surgery trials, as it addresses the primary aims of reducing symptoms and improving healthy survival.
Population
Patients undergoing cardiac surgery, primarily coronary artery bypass graft surgery and aortic or mitral…
Design
Review
Authors
Discussion
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Member takes
Implication
Challenges reliance on surrogates in cardiac surgery trials; extends calls for patient-centered measures but remains hypothesis-generating.
Structured PICO
P
Population
Patients undergoing cardiac surgery, primarily coronary artery bypass graft (CABG) surgery and aortic or mitral valve repair or replacement.
This review highlights the limitations of surrogate and composite endpoints in cardiac surgery trials and advocates for the adoption of disability-free survival as a more meaningful, patient-centered outcome.
Limitations
- Lack of consensus on how to define and quantify disability after cardiac surgery
- Standard measures of disability require urgent study to determine validity and reliability after surgery
Cite This Study
Paul S. Myles (2014) conducted a review in Cardiac surgery. Disability-free survival is proposed as the ideal patient-centered outcome measure for cardiac surgery trials, as it addresses the primary aims of reducing symptoms and improving healthy survival.