Key result
Cardiac surgery in HFrEF is linked to ~8.5% 2-year cardiac mortality and improved hemodynamics.
Why the study?
Chronic congestive heart failure with reduced EF significantly affects survival and hospitalization rates, prompting analysis of cardiac surgery outcomes in this population.
Observational (n=199)
Yes
Cardiac surgery in patients with heart failure and reduced ejection fraction (<50%) is associated with favorable survival rates and significant postoperative improvements in heart function and symptoms.
Answers are grounded in this paper and cite their sources.
May support surgical referral in selected HFrEF patients; leaves open need for randomized confirmation of benefit.
Chronic congestive heart failure with reduced ejection fraction (EF) significantly affects survival and hospitalization rates. This multicenter study analyzed the results of cardiac surgery in patients with heart failure. We used retrospective and prospective analyses and analyzed data from 199 patients with heart failure and EF < 50% who underwent various types of cardiac surgeries, including valve surgery, aortic surgery, and coronary artery bypass grafting. Outcome measures were postoperative heart function and survival rates. The in-hospital mortality rate was 1.0%, while the 2-year cardiac death rate was 8.5%. The freedom from cardiac death rates at 6, 12, and 24 months postoperatively were 97.0%, 94.5%, and 91.5%, respectively. The freedom from readmission from heart failure rates after 6, 12, and 24 months postoperatively were 97.0%, 93.5%, and 88.4%, respectively. In risk factor analysis for mortality at 24 months postoperatively, age (odds ratio [OR], 1.241; 95% confidence interval [CI], 1.083–3.155; p = 0.03), chronic kidney disease with renal replacement therapy (OR, 3.154; 95% CI, 1.333–7.158; p = 0.03), and preoperative lower EF (OR, 0.884; 95% CI, 0.429–0.919; p = 0.04) were significant risk factors. Analysis using linear mixed models demonstrated significant improvements in cardiac hemodynamics and New York Heart Association class postoperatively. In conclusion, cardiac surgery in patients with heart failure showed favorable outcomes with marked improvements in heart function and symptoms.
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Yoon et al. (2025) conducted an observational in Heart failure with reduced ejection fraction (n=199). Cardiac surgery was evaluated on Cardiac death at 2 years. Cardiac surgery in patients with heart failure and reduced ejection fraction resulted in a 2-year cardiac death rate of 8.5% and significant postoperative improvements in cardiac hemodynamics.
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