Key result
Abnormal heart rate diurnal patterns, particularly antiphase patterns, were significantly associated with a higher risk of atrial events (48% vs 19%, p<0.001) compared to normal rhythmic patterns.
Why the study?
Circadian factors likely influence cardiovascular diseases, but the association between diurnal heart rate parameters and CVD risks needed to be determined using Holter and wearable data.
Do abnormal heart rate diurnal patterns correlate with increased cardiovascular disease risk indices?
Observational (n=9,922)
No
Do abnormal heart rate diurnal patterns correlate with increased cardiovascular disease risk indices?
Effect estimate: Diff 0.29
Absolute Event Rate: 48% vs 19%
Absolute Risk Reduction: 29%
p-value: p=<0.001
Extreme or abnormal heart rate diurnal patterns, such as arrhythmic or antiphase patterns, are significantly associated with higher cardiovascular disease risk indices.
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Abnormal diurnal patterns may flag higher atrial event risk; leaves open whether monitoring improves outcomes in prospective studies.
Zhang et al. (2022) conducted an observational in Cardiovascular Diseases (n=9,922). Abnormal heart rate diurnal patterns (arrhythmic or antiphase) vs. Normal rhythmic in-phase heart rate diurnal pattern was evaluated on Atrial events (Diff 0.29, p=<0.001). Abnormal heart rate diurnal patterns, particularly antiphase patterns, were significantly associated with a higher risk of atrial events (48% vs 19%, p<0.001) compared to normal rhythmic patterns.
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