Key result
Slowly increasing heart rate during atrial pacing changed lactate metabolism from production to extraction upon repeat pacing (p<0.02), whereas fast pacing yielded reproducible metabolism.
Why the study?
Does the rate of heart rate increase during atrial pacing affect the reproducibility of pacing-induced myocardial ischaemia?
Population
Patients undergoing atrial pacing to provoke myocardial ischaemia (divided into two groups)
Comparison
Atrial pacing with heart rate slowly increased… vs Comparison between slow and fast pacing protocols
Design
Other
Follow-up
20 minutes of rest between pacing episodes
Authors
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May influence pacing protocol choice in ischaemia testing; leaves open optimal rate standardization for reproducible metabolic studies.
Does the rate of heart rate increase during atrial pacing affect the reproducibility of pacing-induced myocardial ischaemia?
p-value: p=<0.02
The duration of atrial pacing significantly impacts the reproducibility of pacing-induced myocardial ischaemia, with faster pacing protocols yielding more reproducible lactate metabolism results.
Ihlen et al. (2008) studied myocardial ischaemia. Atrial pacing vs. Repeated pacing after 20 min rest was evaluated on Reproducibility of ischaemic lactate metabolism (p=<0.02). Slowly increasing heart rate during atrial pacing changed lactate metabolism from production to extraction upon repeat pacing (p<0.02), whereas fast pacing yielded reproducible metabolism.
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