Key result
Divergent IRES elements enable viruses to recruit host ribosomes and initiate protein synthesis with minimal eukaryotic translation initiation factors, aiding viral gene amplification.
Population
Viruses and host cells
Design
Review
Authors
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May inform IRES-targeted antivirals in viral infections; leaves open cardiovascular translation pending targeted studies.
This review highlights the mechanisms by which viral IRES elements hijack host ribosomes to facilitate viral gene amplification during early innate immune responses.
Cevallos et al. (2005) conducted a review in Viral infection. Divergent IRES elements enable viruses to recruit host ribosomes and initiate protein synthesis with minimal eukaryotic translation initiation factors, aiding viral gene amplification.
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