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June 1, 1994European Heart Journal

Spinal electrical stimulation for intractable angina—long-term clinical outcome and safety

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Why the study?

Does spinal electrical stimulation improve symptoms and provide long-term safety in patients with intractable angina unresponsive to standard therapy?

Population

23 patients with intractable angina unresponsive to standard therapy

Comparison

Spinal cord electrical stimulation vs Pre-operative baseline and stimulator off

Design

Cohort

Follow-up

mean 45 months (range 21-62)

Authors

JSJohn E. SandersonHeart Failure & TransplantBIButhina IbrahimHamad Medical CorporationDWD WaterhouseMusgrove Park Hospital

Discussion

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Implication

Spinal stimulation was associated with symptom and exercise gains in refractory angina; leaves open efficacy confirmation in randomized trials.

Structured PICO

Does spinal electrical stimulation improve symptoms and provide long-term safety in patients with intractable angina unresponsive to standard therapy?

P
Population
23 patients with intractable angina unresponsive to standard therapy
I
Intervention
Spinal cord electrical stimulation (implanted stimulator units)
C
Comparator
Pre-operative baseline and stimulator off (for treadmill exercise testing)
O
Outcome
Long-term clinical outcome and safety (including NYHA grade, GTN consumption, treadmill exercise time, ischaemic episodes, mortality, and myocardial infarction)patient reported

Spinal electrical stimulation provides sustained symptomatic improvement and is a safe alternative therapy for patients with intractable angina unresponsive to standard treatments.

Limitations

  • Frequent complications related to earlier lead designs

Cite This Study

Sanderson et al. (1994) studied this question.

synapsesocial.com/papers/6a95b57e223f4b595a4f0971https://doi.org/10.1093/oxfordjournals.eurheartj.a060589
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Epidural spinal electrical stimulation for severe angina: a study of its effects on symptoms, exercise tolerance and degree of ischaemia1992 · 130 citations
  2. 2Spinal Cord Stimulation for the Treatment of Refractory Angina Pectoris: A Two‐Year Follow‐Up1999 · 50 citations
  3. 3Spinal cord stimulation for refractory angina pectoris: a case series2023 · 1 citations
  4. 4Sequelae of spinal cord stimulation for refractory angina pectoris. Reliability and safety profile of long-term clinical application1997 · 55 citations
  5. 5Effect of spinal cord stimulation on heart rate variability and myocardial ischemia in patients with chronic intractable angina pectoris—A prospective ambulatory electrocardiographic study1998 · 61 citations