Key result
Flecainide in association with amiodarone induced bundle-branch reentrant ventricular tachycardia and recurrent syncope, which resolved upon flecainide withdrawal.
Population
42-year-old male with cardiomyopathy and paroxysmal atrial fibrillation (n=1)
Comparison
Flecainide 400 mg/day added to chronic oral… vs Flecainide withdrawal
Design
Case_report
Follow-up
2 months on therapy, 3 weeks post-withdrawal
Authors
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Potential proarrhythmia warrants caution combining flecainide with amiodarone; single case leaves open need for systematic study.
Case Report (n=1)
The combination of flecainide and amiodarone can exert a significant proarrhythmic effect, potentially inducing bundle-branch reentrant ventricular tachycardia due to intraventricular conduction depression.
Saoudi et al. (1988) conducted a case report in Cardiomyopathy and paroxysmal atrial fibrillation (n=1). Flecainide in association with amiodarone vs. Flecainide withdrawal was evaluated on Bundle-branch reentrant ventricular tachycardia and syncope. Flecainide in association with amiodarone induced bundle-branch reentrant ventricular tachycardia and recurrent syncope, which resolved upon flecainide withdrawal.
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