January 1, 2008Critical Care Medicine
Increasing amiodarone use in cardiopulmonary resuscitation: An analysis of the National Registry of Cardiopulmonary Resuscitation
Key result
Amiodarone use for adult in-hospital VF/pVT increased from 25% in 2000 to 72% in 2005 (p<0.0001), and was positively associated with larger intensive care units (OR 1.825; 95% CI 1.694-1.966).
Population
30,105 patients with an in-hospital ventricular fibrillation or pulseless ventricular tachycardia event…
Design
Cohort
Authors
Discussion
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Implication
Amiodarone adoption for in-hospital VF/pVT rose in larger ICUs; leaves open how hospital factors shape resuscitation practices and needs prospective confirmation.
Study Design
Type
Cohort (n=30,105)
Multicenter
Yes
Structured PICO
P
Population
30,105 patients (29,552 adults and 553 children) with an in-hospital ventricular fibrillation or pulseless ventricular tachycardia event between 2000 and 2005.
E
Exposure
Amiodarone administration during cardiopulmonary resuscitation
O
Outcome
Practice patterns of amiodarone use over time and the impact of hospital and patient specific factors on its use
Main Result
Absolute Event Rate: 72% vs 25%
p-value: p=< .0001
Amiodarone use for in-hospital VF/pVT significantly increased between 2000 and 2005, reflecting the impact of emerging data and national guidelines on resuscitation practice patterns.
Limitations
- It is not possible to determine from the database the order in which medications were administered.
- Not possible to determine from the database the order in which medications were administered
Cite This Study
October et al. (2008) conducted a cohort in In-hospital ventricular fibrillation (VF) or pulseless ventricular tachycardia (pVT) (n=30,105). Amiodarone vs. Time (2000 vs 2005) and hospital factors was evaluated on Amiodarone use for VF/pVT in adults in 2005 compared to 2000 (p=< .0001). Amiodarone use for adult in-hospital VF/pVT increased from 25% in 2000 to 72% in 2005 (p<0.0001), and was positively associated with larger intensive care units (OR 1.825; 95% CI 1.694-1.966).