ISOSENSITIZATION TO A NEW BLOOD FACTOR, RhD, WITH SPECIAL REFERENCE TO ITS CLINICAL IMPORTANCE

Article1 October 1959ISOSENSITIZATION TO A NEW BLOOD FACTOR, RhD, WITH SPECIAL REFERENCE TO ITS CLINICAL IMPORTANCEMILTON S. SACKS, M.D., F.A.C.P., ALEXANDER S. WIENER, M.D., F.A.C.P., ELSA F. JAHN, B.S., CARROLL L. SPURLING, M.D., LESTER J. UNGER, M.D.MILTON S. SACKS, M.D., F.A.C.P.Search for more papers by this author, ALEXANDER S. WIENER, M.D., F.A.C.P.Search for more papers by this author, ELSA F. JAHN, B.S.Search for more papers by this author, CARROLL L. SPURLING, M.D.Search for more papers by this author, LESTER J. UNGER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-51-4-740 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptImmediately following the announcement of the discovery of the Rh factor by Landsteiner and Wiener1two decades ago came the demonstration of the role of Rh sensitization in the causation of hemolytic transfusion reactions,2and in the pathogenesis of erythroblastosis fetalis.3As a result, routine Rh testing has become an essential part of the management of expectant mothers and of the selection of donors for blood transfusion. Study of serums from isosensitized patients has demonstrated that while the bulk of clinical problems are caused by sensitization to the originally described rhesus factor, now designatedRho†, many other blood factors belonging...Bibliography1. LandsteinerWiener KAS: An agglutinable factor in human blood recognized by immune sera for rhesus blood, Proc. Soc. Exper. Biol. and Med. 43: 223, 1940. CrossrefGoogle Scholar2. WienerPeters ASHR: Hemolytic reactions following transfusions of blood of the homologous group, with two cases in which the same agglutinogen was responsible, Ann. Int. Med. 13: 2306, 1940. LinkGoogle Scholar3. LevineKatzinBurnham PEML: Isoimmunization in pregnancy; its possible bearing in the etiology of erythroblastosis fetalis, J. A. M. A. 116: 825, 1941. CrossrefGoogle Scholar4. WienerWexler ASIB: Heredity of the blood groups, 1958, Grune & Stratton, New York. Google Scholar5. Wiener AS: Rh-Hr blood types. Applications in clinical and legal medicine and anthropology, 1954, Grune & Stratton, New York. CrossrefGoogle Scholar6. Wiener AS: Rh-Hr syllabus, 1954, Grune & Stratton, New York. Google Scholar7. WienerUnger ASLJ: Rh factors related to the Rho factor as a source of clinical problems. Diagrammatic representation of their reactions and prediction of still undiscovered Rh factors, J. A. M. A. 169: 696, 1959. CrossrefMedlineGoogle Scholar8. Shapiro M: ABO, MN, P and Rh blood group systems in South African Bantu. Genetic study, South African M. J. 25: 187, 1951. Google Scholar9. ArgallBallTrentleman CIJME: Presence of anti-D antibody in serum of Du patient, J. Lab. and Clin. Med. 41: 895, 1953. MedlineGoogle Scholar10. WienerGeigerGordon ASJEB: Mosaic nature of the Rho blood factor, Exper. Med. and Surg. 15: 75, 1957. MedlineGoogle Scholar11. UngerWienerWeiner LJASL: A new antibody (anti-RhB ) in an Rh-positive patient resulting from blood transfusion, J. A. M. A. 170: 1380, 1959. CrossrefMedlineGoogle Scholar12. UngerWiener LJAS: A new antibody, anti-RhC resulting from isosensitization by pregnancy, with special reference to the heredity of a new Rh-Hr agglutinogen, Rhc 2 , J. Lab. and Clin. Med., in press. Google Scholar13. UngerWienerKatz LJASL: Studies on the blood factors RhA, RhB , and RhC , J. Exper. Med., in press. Google Scholar14. UngerWiener LJAS: Observations on blood factors RhA, Rhα, RhB , and RhC , Am. J. Clin. Path. 31: 95, 1959. CrossrefMedlineGoogle Scholar15. UngerWiener LJAS: Some observations on the blood factors RhA, RhB , and RhC of the Rh-Hr blood group system, Blood 14: 522, 1959. CrossrefMedlineGoogle Scholar16. RosenfieldHaberGibble REGN: New Rh variant, Proc. 6th Cong. Internat. Soc. Transf., N. Y., S. Karger, 1958, pp. 90-95. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication June 9, 1959.From the Baltimore Rh Typing Laboratory, the Department of Medicine (Division of Clinical Pathology), University of Maryland School of Medicine, the Serological Laboratory of the Office of the Chief Medical Examiner of New York City, and the Blood and Plasma Bank of the New York University-Bellevue Medical Center, New York, N. Y.†In this paper, in conformity with the recommendation of the Committee on Medicolegal Problems of the American Medical Association, symbols for agglutinogens and phenotypes are printed in regular type, symbols for blood factors and their corresponding antibodies in boldface type, while symbols for genes and genotypes are printed in italics.Requests for reprints should be addressed to Milton S. Sacks, M.D., University Hospital, Baltimore 1, Maryland. 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