Key result
Lipoprotein lipase gene variants rs326, rs328, and rs13702 were significantly associated with longitudinal changes in triglycerides and HDL-C over 20 years in European Americans (P<0.05).
Why the study?
Do lipoprotein lipase gene polymorphisms influence longitudinal plasma lipid trends in young adults?
Cohort (n=4,161)
Do lipoprotein lipase gene polymorphisms influence longitudinal plasma lipid trends in young adults?
p-value: p=<0.05
Lipoprotein lipase gene variants interact with aging to influence longitudinal lipid trajectories, with significant population-related heterogeneity between European and African Americans.
No takes yet. Share an insight, caveat, or question.
LPL variants should not yet guide lipid care in young adults; leaves open ancestry-specific effects on longitudinal triglycerides and HDL-C.
Tang et al. (2010) reported a cohort. Lipoprotein lipase gene polymorphisms (rs326, rs328, rs13702) vs. Other genotypes was evaluated on Longitudinal changes in triglycerides and HDL-C (p=<0.05). Lipoprotein lipase gene variants rs326, rs328, and rs13702 were significantly associated with longitudinal changes in triglycerides and HDL-C over 20 years in European Americans (P<0.05).
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