Key result
Switching from propofol to etomidate during electroconvulsive therapy led to greater seizure duration, improved EEG seizure quality, and prevented the need for restimulation.
Why the study?
It was unknown whether switching from propofol to etomidate during an electroconvulsive therapy course improves seizure quality in convulsion-resistant patients.
Does switching from propofol to etomidate improve seizure quality in convulsion-resistant patients undergoing electroconvulsive therapy?
Observational (n=33)
Does switching from propofol to etomidate improve seizure quality in convulsion-resistant patients undergoing electroconvulsive therapy?
Switching from propofol to etomidate during electroconvulsive therapy improves seizure duration and EEG quality in convulsion-resistant patients.
May aid seizure optimization in resistant ECT; hypothesis-generating pending randomized trials.
The purpose of this study was to assess whether switching propofol to etomidate during an electroconvulsive therapy course improves seizure quality in convulsion-resistant patients. A retrospective study of paired cases included thirty-three patients. Seizure variables for each agent were assessed. A generalized linear mixed model (GLMM) for repeated measures was used for the analysis. Anesthesia with etomidate leads to greater seizure duration, improved seizure quality in the EEG register, and prevents further need for restimulation; although did not differ from propofol in the amount of energy delivered or in other automated parameters. These results suggest that this procedure appears to be an adequate strategy to improve seizure quality.
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Alcoverro-Fortuny et al. (2019) conducted an observational in Convulsion-resistant patients undergoing electroconvulsive therapy (n=33). Etomidate vs. Propofol was evaluated on Seizure quality and duration. Switching from propofol to etomidate during electroconvulsive therapy led to greater seizure duration, improved EEG seizure quality, and prevented the need for restimulation.
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