What question did this study set out to answer?

To compare the clinical efficacy, seizure variables, and adverse effect profiles of etomidate versus propofol anesthesia during electroconvulsive therapy for major depressive disorder.

July 3, 2023Brain SciencesOpen Access

Etomidate versus Propofol for Electroconvulsive Therapy in Patients with Major Depressive Disorders in Terms of Clinical Responses to Treatment: A Retrospective Analysis

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Authors

IYIn‐Young YoonSeoul National University JRJung‐Hee RyuSeoul National University SDSang-Hwan DoSeoul National University

Discussion

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Implication

Retrospective analysis finds longer seizure durations with etomidate than propofol in major depressive disorder, indicating comparable overall clinical efficacy at discharge.

Key Points

To compare the clinical efficacy, seizure variables, and adverse effect profiles of etomidate versus propofol anesthesia during electroconvulsive therapy for major depressive disorder.
Retrospective analysis of patients with major depressive disorder receiving electroconvulsive therapy with etomidate (n = 43) or propofol (n = 12).
Assessed motor and electroencephalogram seizure durations, seizure intensity, seizure threshold, and hemodynamic changes.
Evaluated clinical response via the Clinical Global Impression scale, mood ratings at discharge, and documented adverse events.
Etomidate anesthesia resulted in significantly longer motor seizure duration (42.0 vs. 23.65 s, p < 0.001) and electroencephalogram seizure duration (51.8 vs. 33.5 s, p < 0.001) compared to propofol.
Scores on the Clinical Global Impression scale, mood at discharge, and rates of adverse events showed no statistically significant differences between groups (p > 0.05).

Cite This Study

Yoon et al. (2023) studied this question.

synapsesocial.com/papers/6a95c2108cd27757a8d037db https://doi.org/10.3390/brainsci13071023

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Implication

Retrospective analysis finds longer seizure durations with etomidate than propofol in major depressive disorder, indicating comparable overall clinical efficacy at discharge.

Etomidate versus Propofol for Electroconvulsive Therapy in Patients with Major Depressive Disorders in Terms of Clinical Responses to Treatment: A Retrospective Analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

Etomidate versus Propofol for Electroconvulsive Therapy in Patients with Major Depressive Disorders in Terms of Clinical Responses to Treatment: A Retrospective Analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

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