Key result
Homozygosity for the Asp298 variant of the 894G>T polymorphism in the eNOS gene was not significantly associated with the risk of acute myocardial infarction (RR 1.08, p=0.663).
Why the study?
Does the 894G>T polymorphism in the eNOS gene increase the risk of acute myocardial infarction in the Greek population?
Case-Control (n=2,329)
Yes
Does the 894G>T polymorphism in the eNOS gene increase the risk of acute myocardial infarction in the Greek population?
Relative Risk: 1.08 (95% CI 0.77–1.51)
p-value: p=0.663
This large case-control study found no significant association between the 894G>T polymorphism in the eNOS gene and the risk of acute myocardial infarction, challenging previous smaller positive association studies.
No support for eNOS genotyping in AMI risk assessment; challenges prior positive reports but leaves association open in other groups.
BACKGROUND: This study was designed to investigate the association of the 894G>T polymorphism in the eNOS gene with risk of acute myocardial infarction (AMI), extent of coronary artery disease (CAD) on coronary angiography, and in-hospital mortality after AMI. METHODS: We studied 1602 consecutive patients who were enrolled in the GEMIG study. The control group was comprised by 727 individuals, who were randomly selected from the general adult population. RESULTS: The prevalence of the Asp298 variant of eNOS was not found to be significantly and independently associated with risk of AMI (RR = 1.08, 95%CI = 0.77-1.51, P = 0.663), extent of CAD on angiography (OR = 1.18, 95%CI = 0.63-2.23, P = 0.605) and in-hospital mortality (RR = 1.08, 95%CI = 0.29-4.04, P = 0.908). CONCLUSION: In contrast to previous reports, homozygosity for the Asp298 variant of the 894G>T polymorphism in the eNOS gene was not found to be associated with risk of AMI, extent of CAD and in-hospital mortality after AMI.
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Andrikopoulos et al. (2008) conducted a case-control in Acute myocardial infarction (n=2,329). 894G>T polymorphism (Asp298 variant) in the eNOS gene vs. Non-carriers of the Asp298 variant was evaluated on Risk of acute myocardial infarction (RR 1.08, 95% CI 0.77-1.51, p=0.663). Homozygosity for the Asp298 variant of the 894G>T polymorphism in the eNOS gene was not significantly associated with the risk of acute myocardial infarction (RR 1.08, p=0.663).
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