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March 9, 2004CirculationOpen Access

Endothelial Nitric Oxide Synthase Genotype and Ischemic Heart Disease

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Why the study?

Does homozygosity for eNOS gene polymorphisms increase the risk of ischemic heart disease?

Population

23,028 individuals from 26 case-control studies evaluating ischemic heart disease

Comparison

Homozygosity for eNOS gene polymorphisms vs Non-homozygous/wild-type genotypes

Design

Meta-analysis

Authors

JCJuan P. CasasLBLeonelo E. BautistaSHSteve E. Humphries

Discussion

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Overview

May modestly raise IHD risk in homozygotes; supports genetic contribution to atherosclerosis susceptibility but leaves causality open.

Structured PICO

Does homozygosity for eNOS gene polymorphisms increase the risk of ischemic heart disease?

P
Population
23,028 individuals (9,867 cases and 13,161 controls) from 26 case-control studies evaluating ischemic heart disease
I
Intervention
Homozygosity for eNOS gene polymorphisms (Asp298, the -786C allele in the promoter, or the intron-4a allele)
C
Comparator
Non-homozygous/wild-type genotypes
O
Outcome
Ischemic heart disease (IHD)hard clinical

Individuals homozygous for the Asp298 and intron-4a alleles of eNOS are at moderately increased risk of ischemic heart disease, supporting a genetic contribution to atherosclerosis susceptibility.

Limitations

  • Significant heterogeneity among studies of Asp298

Cite This Study

Casas et al. (2004) studied this question.

synapsesocial.com/papers/6a7cd7a54fd5c1e90ea1e2behttps://doi.org/10.1161/01.cir.0000121357.76910.a3
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Endothelial Nitric Oxide Synthase Gene Polymorphism and Acute Myocardial Infarction1998 · 355 citations
  2. 2Lack of association between eNOS gene polymorphisms and ischemic heart disease in the Spanish population2002 · 16 citations
  3. 3Genetic and Environmental Determinants of Plasma Nitrogen Oxides and Risk of Ischemic Heart Disease2001 · 124 citations
  4. 4T<sup>−786</sup>→C Mutation in the 5′-Flanking Region of the Endothelial Nitric Oxide Synthase Gene Is Associated With Coronary Spasm1999 · 783 citations
  5. 5G894T Polymorphism in the Endothelial Nitric Oxide Synthase Gene Is Associated With an Enhanced Vascular Responsiveness to Phenylephrine1999 · 181 citations